tuberculosis screening among ambulatory people living with hiv a systematic review CORD-Papers-2022-06-02 (Version 1)

Title: Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis
Abstract: BACKGROUND: The WHO-recommended tuberculosis screening and diagnostic algorithm in ambulatory people living with HIV is a four-symptom screen (known as the WHO-recommended four symptom screen [W4SS]) followed by a WHO-recommended molecular rapid diagnostic test (eg Xpert MTB/RIF [hereafter referred to as Xpert]) if W4SS is positive. To inform updated WHO guidelines we aimed to assess the diagnostic accuracy of alternative screening tests and strategies for tuberculosis in this population. METHODS: In this systematic review and individual participant data meta-analysis we updated a search of PubMed (MEDLINE) Embase the Cochrane Library and conference abstracts for publications from Jan 1 2011 to March 12 2018 done in a previous systematic review to include the period up to Aug 2 2019. We screened the reference lists of identified pieces and contacted experts in the field. We included prospective cross-sectional observational studies and randomised trials among adult and adolescent (age 10 years) ambulatory people living with HIV irrespective of signs and symptoms of tuberculosis. We extracted study-level data using a standardised data extraction form and we requested individual participant data from study authors. We aimed to compare the W4SS with alternative screening tests and strategies and the WHO-recommended algorithm (ie W4SS followed by Xpert) with Xpert for all in terms of diagnostic accuracy (sensitivity and specificity) overall and in key subgroups (eg by antiretroviral therapy [ART] status). The reference standard was culture. This study is registered with PROSPERO CRD42020155895. FINDINGS: We identified 25 studies and obtained data from 22 studies (including 15 666 participants; 4347 [277%] of 15 663 participants with data were on ART). W4SS sensitivity was 82% (95% CI 72-89) and specificity was 42% (29-57). C-reactive protein (10 mg/L) had similar sensitivity to (77% [61-88]) but higher specificity (74% [61-83]; n=3571) than W4SS. Cough (lasting 2 weeks) haemoglobin (<10 g/dL) body-mass index (<185 kg/m2) and lymphadenopathy had high specificities (80-90%) but low sensitivities (29-43%). The WHO-recommended algorithm had a sensitivity of 58% (50-66) and a specificity of 99% (98-100); Xpert for all had a sensitivity of 68% (57-76) and a specificity of 99% (98-99). In the one study that assessed both the sensitivity of sputum Xpert Ultra was higher than sputum Xpert (73% [62-81] vs 57% [47-67]) and specificities were similar (98% [96-98] vs 99% [98-100]). Among outpatients on ART (4309 [991%] of 4347 people on ART) W4SS sensitivity was 53% (35-71) and specificity was 71% (51-85). In this population a parallel strategy (two tests done at the same time) of W4SS with any chest x-ray abnormality had higher sensitivity (89% [70-97]) and lower specificity (33% [17-54]; n=2670) than W4SS alone; at a tuberculosis prevalence of 5% this strategy would require 379 more rapid diagnostic tests per 1000 people living with HIV than W4SS but detect 18 more tuberculosis cases. Among outpatients not on ART (11 160 [718%] of 15 541 outpatients) W4SS sensitivity was 85% (76-91) and specificity was 37% (25-51). C-reactive protein (10 mg/L) alone had a similar sensitivity to (83% [79-86]) but higher specificity (67% [60-73]; n=3187) than W4SS and a sequential strategy (both test positive) of W4SS then C-reactive protein (5 mg/L) had a similar sensitivity to (84% [75-90]) but higher specificity than (64% [57-71]; n=3187) W4SS alone; at 10% tuberculosis prevalence these strategies would require 272 and 244 fewer rapid diagnostic tests per 1000 people living with HIV than W4SS but miss two and one more tuberculosis cases respectively. INTERPRETATION: C-reactive protein reduces the need for further rapid diagnostic tests without compromising sensitivity and has been included in the updated WHO tuberculosis screening guidelines. However C-reactive protein data were scarce for outpatients on ART necessitating future research regarding the utility of C-reactive protein in this group. Chest x-ray can be useful in outpatients on ART when combined with W4SS. The WHO-recommended algorithm has suboptimal sensitivity; Xpert for all offers slight sensitivity gains and would have major resource implications. FUNDING: World Health Organization.
Published: 2022
Journal: Lancet Infect Dis
DOI: 10.1016/s1473-3099(21)00387-x
DOI_URL: http://doi.org/10.1016/s1473-3099(21)00387-x
Author Name: Dhana Ashar
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Author Name: Kengne Andre P
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Author Name: Kerkhoff Andrew D
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Author Name: Merle Corinne S
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Author Name: Shapiro Adrienne E
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Author Name: Churchyard Gavin
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Author Name: Nguyen Duc T
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Author Name: Graviss Edward A
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Author Name: Bjerrum Stephanie
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Author Name: Johansen Isik S
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Author Name: Horne David J
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Author Name: LaCourse Sylvia M
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Author Name: Al Darraji Haider Abdulrazzaq Abed
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Author Name: Kamarulzaman Adeeba
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Author Name: Kempker Russell R
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license: unk
license_url: [unknown license]
source_x: Medline; WHO
source_x_url: https://www.medline.com/https://www.who.int/
pubmed_id: 34800394
pubmed_id_url: https://www.ncbi.nlm.nih.gov/pubmed/34800394
who_covidence_id: #covidwho-1839425
url: https://doi.org/10.1016/s1473-3099(21)00387-x https://www.ncbi.nlm.nih.gov/pubmed/34800394/
has_full_text: FALSE
G_ID: tuberculosis_screening_among_ambulatory_people_living_with_hiv_a_systematic_review