prevalence of sars cov 2 antibodies from a one year national serosurveillance of kenyan CORD-Papers-2022-06-02 (Version 1)

Title: Prevalence of SARS-CoV-2 Antibodies from a one-year National Serosurveillance of Kenyan Blood Transfusion Donors
Abstract: In tropical Africa SARS-CoV-2 epidemiology is poorly described because of lack of access to testing and weak surveillance systems. Since April 2020 we followed SARS-CoV-2 seroprevalence in plasma samples across the Kenya National Blood Transfusion Service. We developed an IgG ELISA against full length spike protein. Validated in locally-observed PCR-positive COVID-19 cases and in pre-pandemic sera sensitivity was 92.7% and specificity was 99.0%. Using sera from 9922 donors we estimated national seroprevalence of SARS-CoV-2 antibodies at 4.3% in April-June 2020 and 9.1% in August-September 2020. Kenyas second COVID-19 wave peaked in November 2020. Here we estimate national seroprevalence in early 2021. Between January 3 and March 15 2021 we collected 3062 samples from donors aged 16-64 years. Among 3018 samples that met our study criteria 1333 were seropositive (crude seroprevalence 44.2% 95% CI 42.4-46.0%). After Bayesian test-performance adjustment and population weighting to represent the national population distribution the national estimate of seroprevalence was 48.5% (95% CI 45.2-52.1%). Seroprevalence varied little by age or sex but was higher in Nairobi (61.8%) the capital city and lower in two rural regions. Almost half of Kenyas adult donors had evidence of past SARS-CoV-2 infection by March 2021. Although high the estimate is corroborated by other population-specific estimates in country. Between March and June 2% of the population were vaccinated against COVID-19 and the country experienced a third epidemic wave. Natural infection is outpacing vaccine delivery substantially in Africa and this reality needs to be considered as objectives of the vaccine programme are set.
Published: 2021
Author Name: Uyoga Sophie
Author link: https://covid19-data.nist.gov/pid/rest/local/author/uyoga_sophie
Author Name: Adetifa Ifedayo M O
Author link: https://covid19-data.nist.gov/pid/rest/local/author/adetifa_ifedayo_m_o
Author Name: Otiende Mark
Author link: https://covid19-data.nist.gov/pid/rest/local/author/otiende_mark
Author Name: Gitonga John
Author link: https://covid19-data.nist.gov/pid/rest/local/author/gitonga_john
Author Name: Mugo Daisy
Author link: https://covid19-data.nist.gov/pid/rest/local/author/mugo_daisy
Author Name: Nyagwange James
Author link: https://covid19-data.nist.gov/pid/rest/local/author/nyagwange_james
Author Name: Karanja Henry K
Author link: https://covid19-data.nist.gov/pid/rest/local/author/karanja_henry_k
Author Name: Tuju James
Author link: https://covid19-data.nist.gov/pid/rest/local/author/tuju_james
Author Name: Makale Johnstone
Author link: https://covid19-data.nist.gov/pid/rest/local/author/makale_johnstone
Author Name: Aman Rashid
Author link: https://covid19-data.nist.gov/pid/rest/local/author/aman_rashid
Author Name: Mwangangi Mercy
Author link: https://covid19-data.nist.gov/pid/rest/local/author/mwangangi_mercy
Author Name: Amoth Patrick
Author link: https://covid19-data.nist.gov/pid/rest/local/author/amoth_patrick
Author Name: Kasera Kadondi
Author link: https://covid19-data.nist.gov/pid/rest/local/author/kasera_kadondi
Author Name: Ng Wangari
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ng_wangari
Author Name: ang
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ang
Author Name: Kilonzo Nduku
Author link: https://covid19-data.nist.gov/pid/rest/local/author/kilonzo_nduku
Author Name: Chege Evelynn
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chege_evelynn
Author Name: Yegon Christine
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yegon_christine
Author Name: Odhiambo Elizabeth
Author link: https://covid19-data.nist.gov/pid/rest/local/author/odhiambo_elizabeth
Author Name: Rotich Thomas
Author link: https://covid19-data.nist.gov/pid/rest/local/author/rotich_thomas
Author Name: Orgut Irene
Author link: https://covid19-data.nist.gov/pid/rest/local/author/orgut_irene
Author Name: Kihara Sammy
Author link: https://covid19-data.nist.gov/pid/rest/local/author/kihara_sammy
Author Name: Bottomley Christian
Author link: https://covid19-data.nist.gov/pid/rest/local/author/bottomley_christian
Author Name: Kagucia E Wangeci
Author link: https://covid19-data.nist.gov/pid/rest/local/author/kagucia_e_wangeci
Author Name: Gallagher Katherine
Author link: https://covid19-data.nist.gov/pid/rest/local/author/gallagher_katherine
Author Name: Etyang Anthony O
Author link: https://covid19-data.nist.gov/pid/rest/local/author/etyang_anthony_o
Author Name: Voller Shirine
Author link: https://covid19-data.nist.gov/pid/rest/local/author/voller_shirine
Author Name: Lambe Teresa
Author link: https://covid19-data.nist.gov/pid/rest/local/author/lambe_teresa
Author Name: Wright Daniel
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wright_daniel
Author Name: Barasa Edwine
Author link: https://covid19-data.nist.gov/pid/rest/local/author/barasa_edwine
Author Name: Tsofa Benjamin
Author link: https://covid19-data.nist.gov/pid/rest/local/author/tsofa_benjamin
Author Name: Mwangangi Joseph
Author link: https://covid19-data.nist.gov/pid/rest/local/author/mwangangi_joseph
Author Name: Bejon Philip
Author link: https://covid19-data.nist.gov/pid/rest/local/author/bejon_philip
Author Name: Ochola Oyier Lynette I
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ochola_oyier_lynette_i
Author Name: Warimwe George M
Author link: https://covid19-data.nist.gov/pid/rest/local/author/warimwe_george_m
Author Name: Agweyu Ambrose
Author link: https://covid19-data.nist.gov/pid/rest/local/author/agweyu_ambrose
Author Name: Scott J Anthony G
Author link: https://covid19-data.nist.gov/pid/rest/local/author/scott_j_anthony_g
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #ppmedrxiv-21260038
has_full_text: FALSE
G_ID: prevalence_of_sars_cov_2_antibodies_from_a_one_year_national_serosurveillance_of_kenyan