ktrcv392 CORD-Papers-2022-06-02 (Version 1)

Title: Trachoma.
Abstract: Trachoma is a neglected tropical disease caused by infection with conjunctival strains of Chlamydia trachomatis. It can result in blindness. Pathophysiologically trachoma is a disease complex composed of two linked chronic processes: a recurrent generally subclinical infectious-inflammatory disease that mostly affects children and a non-communicable cicatricial and owing to trichiasis eventually blinding disease that supervenes in some individuals later in life. At least 150 infection episodes over an individual's lifetime are needed to precipitate trichiasis; thus opportunity exists for a just global health system to intervene to prevent trachomatous blindness. Trachoma is found at highest prevalence in the poorest communities of low-income countries particularly in sub-Saharan Africa; in June 2021 1.8 million people worldwide were going blind from the disease. Blindness attributable to trachoma can appear in communities many years after conjunctival C. trachomatis transmission has waned or ceased; therefore the two linked disease processes require distinct clinical and public health responses. Surgery is offered to individuals with trichiasis and antibiotic mass drug administration and interventions to stimulate facial cleanliness and environmental improvement are designed to reduce infection prevalence and transmission. Together these interventions comprise the SAFE strategy which is achieving considerable success. Although much work remains a continuing public health problem from trachoma in the year 2030 will be difficult for the world to excuse.
Published: 2022-05-26
Journal: Nature reviews. Disease primers
DOI: 10.1038/s41572-022-00359-5
DOI_URL: http://doi.org/10.1038/s41572-022-00359-5
Author Name: Solomon Anthony W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/solomon_anthony_w
Author Name: Burton Matthew J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/burton_matthew_j
Author Name: Gower Emily W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/gower_emily_w
Author Name: Harding Esch Emma M
Author link: https://covid19-data.nist.gov/pid/rest/local/author/harding_esch_emma_m
Author Name: Oldenburg Catherine E
Author link: https://covid19-data.nist.gov/pid/rest/local/author/oldenburg_catherine_e
Author Name: Taylor Hugh R
Author link: https://covid19-data.nist.gov/pid/rest/local/author/taylor_hugh_r
Author Name: Traor Lamine
Author link: https://covid19-data.nist.gov/pid/rest/local/author/traor_lamine
license: unk
license_url: [unknown license]
source_x: Medline
source_x_url: https://www.medline.com/
pubmed_id: 35618795
pubmed_id_url: https://www.ncbi.nlm.nih.gov/pubmed/35618795
url: https://doi.org/10.1038/s41572-022-00359-5 https://www.ncbi.nlm.nih.gov/pubmed/35618795/
has_full_text: FALSE
G_ID: ktrcv392