expressions of multiple inflammation markers in the patients with covid 19 and their CORD-Papers-2021-10-25 (Version 1)

Title: Expressions of multiple inflammation markers in the patients with COVID-19 and their clinical values
Abstract: Objective: To explore the expressions of multiple inflammation markers in the patients with COVID-19 and their clinical values, and to provide theoretical basis for clinical diagnosis and treatment Methods: A total of 164 patients, diagnosed with COVID-19 and admitted to Guangzhou Eighth People's Hospital from January to February 2020, were selected as the research group and divided into three groups (ordinary, severe, and critically severe pneumonia) according to the disease severity Meanwhile 66 non-infected patients during the same period were selected as negative control group The expressions of white blood cell (WBC), lymphocyte (LYM), C-reactive protein (CRP), serum amyloid A protein (SAA), and procalcitonin (PCT) were retrospective studied and compared between groups The diagnostic values of WBC, CRP, SAA and the combination of these three markers in all patients with COVID-19 and in different severity groups were analyzed by receiver operator characteristic (ROC) curve Results: Compared with control group [WBC count:8 13(6 51,9 42)109/L, LYM count:2 00(1 28,2 43)109/L], WBC count [4 94(4 05, 6 67) 109/L] and LYM count [1 33(0 94, 1 96) 109/L] of COVID-19 patients were significantly reduced (Z=-7 435, P<0 01;Z=-4 906, P<0 01) Compared with the control group [CRP: 1 36 (0 57~5 67) mg/ml;SAA:4 98 (4 80-15 75) mg/ml], CRP [7 93 (2 45-23 98) mg/ml] and SAA [34 13 (4 83-198 40) mg/ml] were increased in research group (Z=-5 72, P<0 01;Z=-4 166, P<0 01) PCT in the control group and the research group were 0 100 0(0 030 6-0 100 0)ng/ml and 0 044 5(0 031 6-0 077 0)ng/ml, respectively There was no statistical difference between two groups (Z=-1 451, P=0 147) The areas under the receiver operator characteristic curve (AUC) of WBC, CRP and SAA in patients with COVID-19 were 0 814, 0 742, 0 673, respectively (P<0 01), while the AUC of the combination of three indexes for COVID-19 diagnosis was 0 882, with 83 33%(55/66) specificity and 84 76% (139/164) sensitivity, P<0 01 The AUCs of WBC, CRP, and SAA for predicting severe and critically severe COVID-19 were 0 799, 0 779, and 0 886, respectively (P<0 01) The AUC of the combination of three indexes for the diagnosis of severe and critically severe COVID-19 was 0 924, with 78 67% (118/150) specificity and 14/14 sensitivity (P<0 01) Conclusion: Combining detection of WBC, CRP and SAA can improve the specificity and sensitivity of COVID-19 diagnosis, with a high diagnostic value for severe and critically severe COVID-19
Published: 2020
Journal: Chinese Journal of Laboratory Medicine
Author Name: Shi, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/shi_y
Author Name: Ou, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ou_j
Author Name: Chen, X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_x
Author Name: Tan, M
Author link: https://covid19-data.nist.gov/pid/rest/local/author/tan_m
Author Name: Li, F
Author link: https://covid19-data.nist.gov/pid/rest/local/author/li_f
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #769445
has_full_text: FALSE
G_ID: expressions_of_multiple_inflammation_markers_in_the_patients_with_covid_19_and_their
S2 ID: 216274194