effect of one off complete tumor radiofrequency ablation on liver function and postoperative CORD-Papers-2022-06-02 (Version 1)

Title: Effect of one-off complete tumor radiofrequency ablation on liver function and postoperative complication in small hepatocellular carcinoma.
Abstract: OBJECTIVE Radiofrequency ablation (RFA) is effective in treating hepatocellular carcinoma (HCC) and less invasive than surgical resection. However 'one-off' complete tumor ablation on liver function has not been reported. METHODS We retrospectively reviewed 36 HCCs which met the criteria of 'one-off' complete tumor ablation: (1) tumor was completed covered by the ablated zone (confirmed by postoperative enhanced CT) with a single RFA and (2) no sign of recurrence for at least 6 months. We categorized tumors into two groups: near vascular tumor (NVT) if the distance was less than 5 mm and far vascular tumor (FVT) otherwise. RESULTS Thirteen HCCs met the criteria of NVTs and 23 HCCs met that of FVTs. The Average tumor size was 2.6 0.3 cm in FVTs and 2.5 0.3 cm in NVTs. Although restored to normal range by postoperative day (POD) 7 ALT AST total bilirubin (TB) albumin and prothrombin time showed more significant fluctuation in NVTs compared to those in FVTs on POD1 through POD5. Moreover 53.9% (7/13) patients in NVT group and 26.1% (6/23) in FVT group developed post-RFA transient ascites (OR = 5.1 95% CI = 1.1-24.4). Incidence of post-RFA pleural effusion were 61.5% (8/13) in NVT but only 17.4% (4/23) in FVTs (OR = 7.6 95% CI = 1.6-35.9). CONCLUSION 'One-off' complete tumor ablation may impair liver function and led to more postoperative complication if a tumor is within 5 mm away from a large blood vessel ( 3 mm). Particular caution should be made in preoperative assessment on the anatomic relation between tumor and large blood vessel for patients.
Published: 2014
Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
DOI: 10.1016/j.ejso.2013.12.004
DOI_URL: http://doi.org/10.1016/j.ejso.2013.12.004
Author Name: Jiang K
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jiang_k
Author Name: Dong J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/dong_j
Author Name: Zhang W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_w
Author Name: Liu Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Su M
Author link: https://covid19-data.nist.gov/pid/rest/local/author/su_m
Author Name: Zhao X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhao_x
Author Name: Wang J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_j
Author Name: Yao M
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yao_m
Author Name: Huang Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/huang_z
license: unk
license_url: [unknown license]
source_x: Medline
source_x_url: https://www.medline.com/
pubmed_id: 24387942
pubmed_id_url: https://www.ncbi.nlm.nih.gov/pubmed/24387942
url: https://doi.org/10.1016/j.ejso.2013.12.004 https://www.ncbi.nlm.nih.gov/pubmed/24387942/
has_full_text: FALSE
G_ID: effect_of_one_off_complete_tumor_radiofrequency_ablation_on_liver_function_and_postoperative