dlpalign a deep learning based progressive alignment method for multiple protein CORD-Papers-2021-10-25 (Version 1)

Title: DLPAlign: A Deep Learning based Progressive Alignment Method for Multiple Protein Sequences
Abstract: This paper proposed a novel and straightforward approach to improve the accuracy of progressive multiple protein sequence alignment method We trained a decision-making model based on the convolutional neural networks and bi-directional long short term memory networks, and progressively aligned the input protein sequences by calculating different posterior probability matrices To evaluate this method, we have implemented a multiple sequence alignment tool called DLPAlign and compared its performance with eleven leading alignment methods on three empirical alignment benchmarks (BAliBASE, OXBench and SABMark) Our results show that DLPAlign can get the best total-column scores on the three benchmarks When evaluated against the 711 low similarity families with average PID 30%, DLPAlign improved about 2 8% over the second-best MSA software Besides, we compared the performance of DLPAlign and other alignment tools on a real-life application, namely protein secondary structure prediction on four protein sequences related to SARS-COV-2, and DLPAlign provides the best result in all cases 2020 ACM
Published: 2020
Journal: ACM Int. Conf. Proc. Ser.
Author Name: Kuang, M
Author link: https://covid19-data.nist.gov/pid/rest/local/author/kuang_m
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Gao, L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/gao_l
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #972183
has_full_text: FALSE
G_ID: dlpalign_a_deep_learning_based_progressive_alignment_method_for_multiple_protein
S2 ID: 227069969