cost effectiveness of introducing national seasonal influenza vaccination for adults CORD-Papers-2022-06-02 (Version 1)

Title: Cost-effectiveness of introducing national seasonal influenza vaccination for adults aged 60 years and above in mainland China: a modelling analysis
Abstract: BACKGROUND: China has an aging population with an increasing number of adults aged ≥ 60 years. Influenza causes a heavy disease burden in older adults but can be alleviated by vaccination. We assessed the cost-effectiveness of a potential government-funded seasonal influenza vaccination program in older adults in China. METHODS: We characterized the health and economic impact of a fully funded influenza vaccination program for older adults using China-specific influenza disease burden and related cost data etc. Using a decision tree model we calculated the incremental costs per quality-adjusted life year (QALY) gained of vaccination from the societal perspective at a willingness-to-pay threshold equivalent to GDP per capita (US$8840). Moreover we estimated the threshold vaccination costs under which the fully funded vaccination program is cost-effective using GDP per capita as the willingness-to-pay threshold. RESULTS: Compared to current self-paid vaccination a fully funded vaccination program is expected to prevent 19812 (95% uncertainty interval 7150-35783) influenza-like-illness outpatient consultations per year 9418 (3386-17068) severe acute respiratory infection hospitalizations per year and 8800 (5300-11667) respiratory excess deaths due to influenza per year and gain 70212 (42106-93635) QALYs per year. Nationally the incremental costs per QALY gained of the vaccination program is US$4832 (3460-8307) with a 98% probability of being cost-effective. The threshold vaccination cost is US$10.19 (6.08-13.65). However variations exist between geographical regions with Northeast and Central China having lower probabilities of cost-effectiveness. CONCLUSIONS: Our results support the implementation of a government fully funded older adult vaccination program in China. The regional analysis provides results across settings that may be relevant to other countries with similar disease burden and economic status especially for low- and middle-income countries where such analysis is limited.
Published: 2020
Journal: BMC Med
Author Name: Yang Juan
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yang_juan
Author Name: Atkins Katherine E
Author link: https://covid19-data.nist.gov/pid/rest/local/author/atkins_katherine_e
Author Name: Feng Luzhao
Author link: https://covid19-data.nist.gov/pid/rest/local/author/feng_luzhao
Author Name: Baguelin Marc
Author link: https://covid19-data.nist.gov/pid/rest/local/author/baguelin_marc
Author Name: Wu Peng
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wu_peng
Author Name: Yan Han
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yan_han
Author Name: Lau Eric H Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/lau_eric_h_y
Author Name: Wu Joseph T
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wu_joseph_t
Author Name: Liu Yang
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_yang
Author Name: Cowling Benjamin J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/cowling_benjamin_j
Author Name: Jit Mark
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jit_mark
Author Name: Yu Hongjie
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yu_hongjie
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #661155
has_full_text: FALSE
G_ID: cost_effectiveness_of_introducing_national_seasonal_influenza_vaccination_for_adults