correlation between early plasma interleukin 37 responses with low inflammatory cytokine CORD-Papers-2022-06-02 (Version 1)

Title: Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Abstract: BACKGROUND: The immune protective mechanisms during severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection remain to be deciphered for the development of an effective intervention approach METHODS: We examined early responses of interleukin 37 (IL-37) a powerful anti-inflammatory cytokine in 254 SARS-CoV-2-infected patients before any clinical intervention and determined its correlation with clinical prognosis RESULTS: Our results demonstrated that SARS-CoV-2 infection causes elevation of plasma IL-37 Higher early IL-37 responses were correlated with earlier viral RNA negative conversion chest computed tomographic improvement and cough relief consequently resulted in earlier hospital discharge Further assays showed that higher IL-37 was associated with lower interleukin 6 and interleukin 8 (IL-8) and higher interferon alpha responses and facilitated biochemical homeostasis Low IL-37 responses predicted severe clinical prognosis in combination with IL-8 and C-reactive protein In addition we observed that IL-37 administration was able to attenuate lung inflammation and alleviate respiratory tissue damage in human angiotensin-converting enzyme 2-transgenic mice infected with SARS-CoV-2 CONCLUSIONS: Overall we found that IL-37 plays a protective role by antagonizing inflammatory responses while retaining type I interferon thereby maintaining the functionalities of vital organs IL-37 IL-8 and C-reactive protein might be formulated as a precise prediction model for screening severe clinical cases and have good value in clinical practice
Published: 2021
Journal: Journal of Infectious Diseases
Author Name: Li A
Author link: https://covid19-data.nist.gov/pid/rest/local/author/li_a
Author Name: Ling Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ling_y
Author Name: Song Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/song_z
Author Name: Cheng X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/cheng_x
Author Name: Ding L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ding_l
Author Name: Jiang R
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jiang_r
Author Name: Fu W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/fu_w
Author Name: Liu Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Hu H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/hu_h
Author Name: Yuan S
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yuan_s
Author Name: Chen J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_j
Author Name: Zhu C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhu_c
Author Name: Fan J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/fan_j
Author Name: Wang J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_j
Author Name: Jin Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jin_y
Author Name: Zhang M
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_m
Author Name: Zhu L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhu_l
Author Name: Sun P
Author link: https://covid19-data.nist.gov/pid/rest/local/author/sun_p
Author Name: Zhang L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_l
Author Name: Qin R
Author link: https://covid19-data.nist.gov/pid/rest/local/author/qin_r
Author Name: Zhang W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_w
Author Name: Qiu C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/qiu_c
Author Name: Shen Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/shen_y
Author Name: Shi Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/shi_z
Author Name: Zhao C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhao_c
Author Name: Zhu T
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhu_t
Author Name: Lu H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/lu_h
Author Name: Zhang X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_x
Author Name: Xu J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/xu_j
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #1101847
has_full_text: FALSE
G_ID: correlation_between_early_plasma_interleukin_37_responses_with_low_inflammatory_cytokine