clinical features of severe or critical ill patients with covid 19 CORD-Papers-2021-10-25 (Version 1)

Title: Clinical features of severe or critical ill patients with COVID-19
Abstract: OBJECTIVE: To analyze the clinical features of severe or critical ill adult patients with coronavirus disease (COVID-19) METHODS: The clinical data of 75 patients with severe or critical COVID-19 in Honghu People's Hospital from January to March in 2020 were collected RESULTS: Of the 75 patients with COVID-19 pneumonia, 41 were male (54 67%) and 34 were female (45 33%) with a mean age of 67 53 12 37 years;43 patients had severe and 32 had critical COVID-19, and 49 3% of the patients had underlying diseases The main clinical manifestations included fever (78 67%) and coughing (70 67%) Compared with the severe patients, the critically ill patients had higher proportions of patients over 60 years old with elevated white blood cell count, increased prothrombin time, and higher levels of hsCRP, PCT, D-dimer, ALT, LDH, cTnI and NT-proBNP Univariate logistic regression analysis showed that an age over 60 years, leukocytosis, hs-CRP elevation, prolonged prothrombin time, and increased levels of D-dimer, NT-proBNP and cTnI were associated with severe COVID-19 Multivariate logistic regression showed that an age over 60 years (OR=8 165, 95% CI: 1 483-45 576, P=0 017), prolonged prothrombin time (OR=7 516, 95% CI: 2 568-21 998, P=0 006) and elevated NT-proBNP (OR=6 194, 95% CI: 1 305-29 404, P=0 022) were independent risk factors for critical type of COVID-19 CONCLUSIONS: An age over 60 years, a prolonged prothrombin time and elevated NT-proBNP level are important clinical features of critically ill patients with COVID-19, and can be deemed as early warning signals for critical conditions of the disease
Published: 2020
Journal: Nan Fang Yi Ke Da Xue Xue Bao
Author Name: Xie, W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/xie_w
Author Name: Zhu, S
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhu_s
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Bai, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/bai_y
Author Name: Fu, W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/fu_w
Author Name: Chen, H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_h
Author Name: Chen, Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_z
Author Name: Zhang, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_j
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #749265
has_full_text: FALSE
G_ID: clinical_features_of_severe_or_critical_ill_patients_with_covid_19
S2 ID: 221543120