clinical characteristics of recovered covid 19 patients with re detectable positive CORD-Papers-2021-10-25 (Version 1)

Title: Clinical characteristics of recovered COVID-19 patients with re-detectable positive RNA test
Abstract: Background: The characteristics, significance and potential cause of positive SARS-CoV-2 diagnoses in recovered coronavirus disease 2019 (COVID-19) patients post discharge (re-detectable positive, RP) remained elusive Methods: A total of 262 COVID-19 patients discharged from January 23 to February 25, 2020 were enrolled into this study RP and non-RP (NRP) patients were grouped according to disease severity, and the characterization at re-admission was analyzed SARS-CoV-2 RNA and plasma antibody levels were measured, and all patients were followed up for at least 14 days, with a cutoff date of March 10, 2020 Results: A total of 14 5% of RP patients were detected These patients were characterized as young and displayed mild and moderate conditions compared to NRP patients while no severe patients were RP RP patients displayed fewer symptoms but similar plasma antibody levels during their hospitalization compared to NRP patients Upon hospital readmission, these patients showed no obvious symptoms or disease progression All 21 close contacts of RP patients were tested negative for viral RNA and showed no suspicious symptoms Eighteen out of 24 of RNA-negative samples detected by the commercial kit were tested positive for viral RNA using a hyper-sensitive method, suggesting that these patients were potential carriers of the virus after recovery from COVID-19 Conclusions: Our results indicated that young patients, with a mild diagnosis of COVID-19 are more likely to display RP status after discharge These patients show no obvious symptoms or disease progression upon re-admission More sensitive RNA detection methods are required to monitor these patients Our findings provide information and evidence for the management of convalescent COVID-19 patients
Published: 2020
Journal: Annals of Translational Medicine
Author Name: An, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/an_j
Author Name: Liao, X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liao_x
Author Name: Xiao, T
Author link: https://covid19-data.nist.gov/pid/rest/local/author/xiao_t
Author Name: Qian, S
Author link: https://covid19-data.nist.gov/pid/rest/local/author/qian_s
Author Name: Yuan, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yuan_j
Author Name: Ye, H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ye_h
Author Name: Qi, F
Author link: https://covid19-data.nist.gov/pid/rest/local/author/qi_f
Author Name: Shen, C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/shen_c
Author Name: Wang, L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_l
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Cheng, X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/cheng_x
Author Name: Li, N
Author link: https://covid19-data.nist.gov/pid/rest/local/author/li_n
Author Name: Cai, Q
Author link: https://covid19-data.nist.gov/pid/rest/local/author/cai_q
Author Name: Wang, F
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_f
Author Name: Chen, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_j
Author Name: Li, G
Author link: https://covid19-data.nist.gov/pid/rest/local/author/li_g
Author Name: Wang, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_y
Author Name: Zhang, F
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_f
Author Name: Fu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/fu_y
Author Name: He, Q
Author link: https://covid19-data.nist.gov/pid/rest/local/author/he_q
Author Name: Tan, X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/tan_x
Author Name: Liu, L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_l
Author Name: Zhang, Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_z
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #842908
has_full_text: FALSE
G_ID: clinical_characteristics_of_recovered_covid_19_patients_with_re_detectable_positive
S2 ID: 216465275