association of d dimer inflammatory markers cytokines abnormality and disease severity CORD-Papers-2021-10-25 (Version 1)

Title: Association of D-dimer, inflammatory markers, cytokines abnormality, and disease severity in COVID-19 severe/critical patients in Wuhan
Abstract: Objective: To analyze the association of D-dimer levels, inflammatory indicators, cytokine abnormality, and disease severity in COVID-19 severe/critical type patients Methods: The medical records of 41 patients were collected from a single center in Wuhan from February 8, 2020 to March 25, 2020 The patients were divided into severe type group (28 patients) and critical type group (13 patients) The levels of D-dimer, WBC, ANC, PCT, hsCRP, IL-2R, IL-6, IL-8, and TNF- were compared among patients with different clinical types of COVID-19 infection Moreover, the changes in the cytokines were analyzed in patients with different D-dimer levels And, the levels of D-dimer, IL-2R, IL-6, IL-8, and TNF- before and after anticoagulant therapy were assessed Statistical analyses were performed using Student t test, Mann-Whitney U test, and Chi-square test Results: Among the 41 patients, 23 were men (56 1%) and 18 were women (43 9%) ;the median patient age was 57 y The age of the critical type patients [ (61 110 4) y] was higher than that of severe type patients [ (52 811 7) y];the difference was significant (t=-2 264, P=0 032) The proportion of critical type patients with chronic diseases, especially hypertension, cardiovascular disease, and cerebrovascular disease, was higher as compared to that in those with severe type patients;the differences were significant (all P<0 05) The prevalence of dyspnea, sweats, and fatigue symptoms in the critical type patients was higher than that in those with severe type disease;the differences were significant ((2)=14 898, 6 972, 7 823;P<0 001, 0 008, 0 005) The levels of D-dimer, WBC, ANC, PCT, hsCRP, and IL-8 in critical type patients were higher than those in severe type patients;the differences were significant (all P<0 05) The levels of IL-2R, IL-8, and TNF- in patients with abnormal D-dimer were higher as compared to those in patients with normal D-dimer levels;the differences were significant (all P<0 05) Eight patients were treated with prophylactic anticoagulation;the levels of D-dimer, IL-2R, IL-6 and IL-8 after anticoagulant therapy were lower than those before treatment Conclusions: COVID-19 critical type patients have more serious coagulation-immune dysfunction and dynamic monitoring of D-dimer and cytokines levels helps in identifying critical type patients as early as possible;anticoagulant therapy may improve the patient's condition by correcting coagulation-immune dysfunction
Published: 2020
Journal: Zhonghua Xue Ye Xue Za Zhi
Author Name: Zhang, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_j
Author Name: Gao, X L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/gao_x_l
Author Name: Li, D J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/li_d_j
Author Name: Jiang, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jiang_y
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Pang, L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/pang_l
Author Name: Xu, D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/xu_d
Author Name: Yang, L H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yang_l_h
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #983958
has_full_text: FALSE
G_ID: association_of_d_dimer_inflammatory_markers_cytokines_abnormality_and_disease_severity
S2 ID: 229319091