arsenite induces dysfunction of regulatory t cells through acetylation control of CORD-Papers-2021-10-25 (Version 1)

Title: Arsenite induces dysfunction of regulatory T cells through acetylation control of the Foxp3 promoter
Abstract: Arsenic is known to cause damage to the body's immune system by inducing epigenetic changes. However, the molecular mechanism of this damage remains elusive. Here, we report that arsenic disrupts the morphology of lymphocytes, decreases cell viability, and results in abnormal proportions of T lymphocyte subsets. Moreover, our results revealed that arsenic can reduce global acetylation of histone H4 at K16 (H4K16 ac) in lymphocytes via decreasing the level of males absent on the first but upregulates mRNA and protein levels of the forkhead/winged-helix box P3 (Foxp3) gene by increasing the acetylation of histone H4 at K16 (H4K16) at the promoter of Foxp3. Finally, arsenic-induced dysfunction of regulatory T cells (Tregs) could be ameliorated by trichostatin A. Our research indicates that arsenic-induced immunosuppressive effect in human lymphocytes may be related to the acetylation of H4K16 at the promoter of Foxp3 and that histone deacetylase inhibitors may play a role in the prevention and treatment of immune injury caused by arsenic.
Published: 2020
Journal: Hum Exp Toxicol
Author Name: Chen, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_j
Author Name: Jiang, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jiang_j
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Ye, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ye_y
Author Name: Ma, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ma_y
Author Name: Cen, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/cen_y
Author Name: Chen, W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_w
Author Name: Wang, S
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_s
Author Name: Yang, G
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yang_g
Author Name: Zhang, A
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_a
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #32735129
has_full_text: FALSE
G_ID: arsenite_induces_dysfunction_of_regulatory_t_cells_through_acetylation_control_of
S2 ID: 220887313