analysis of the factors associated with negative conversion of severe acute respiratory CORD-Papers-2021-10-25 (Version 1)

Title: Analysis of the factors associated with negative conversion of severe acute respiratory syndrome coronavirus 2 rna of coronavirus disease 2019
Abstract: AIM: To understand the factors associated with negative conversion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, targeted surveillance and control measures can be taken to provide scientific basis for the treatment of the disease and to improve the prognosis of the disease METHODS: Using the method of retrospective cohort study, we collected the data of Coronavirus Disease 2019 (COVID-19) patients in Tongji Hospital of Wuhan, China from 10 January to 25 March, 2020 Among the data of 282 cases, 271 patients, according to whether the negative conversion happened, were divided into negative conversion group and control group We made the quantitative variables into classification;Chi-square test single-factor and Cox regression were used in univariate analysis and extracted 30 meaningful variables, then through the collinearity diagnosis, excluded the existence of collinear variables Finally, 22 variables were included in Cox regression analysis RESULTS: The gender distribution was statistically significant between two groups (p < 0 05) While in the negative conversion group, the patients of non-severe group occupied a large proportion (p < 0 001) The median time for the negative conversion group was 17 days, and at the end of the observation period, the virus duration in control group was 24 days (p < 0 05) A total of 55 variables were included in univariate analysis, among which 30 variables were statistically different between the two groups After screening variables through collinearity diagnosis, 22 variables were included in the Cox regression analysis Last, lactate dehydrogenase (LDH), age, fibrinogen (FIB), and disease severity were associated with negative conversion of SARS-CoV-2 RNA CONCLUSION: Our results suggest that in the treatment of COVID-19, focus on the age of more than 65 years old, severe, high level of LDH, FIB patients, and take some targeted treatment, such as controlling of inflammation, reducing organ damage, so as to provide good conditions for virus clearance in the body
Published: 2020
Journal: Open Access Macedonian Journal of Medical Sciences
Author Name: Jiang, N
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jiang_n
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Yang, B
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yang_b
Author Name: Li, Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/li_z
Author Name: Si, D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/si_d
Author Name: Ma, P
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ma_p
Author Name: Zhang, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_j
Author Name: Liu, T
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_t
Author Name: Yu, Q
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yu_q
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #993692
has_full_text: FALSE
G_ID: analysis_of_the_factors_associated_with_negative_conversion_of_severe_acute_respiratory
S2 ID: 230652496