analysis of baseline liver biochemical parameters in 324 cases with novel coronavirus CORD-Papers-2021-10-25 (Version 1)

Title: Analysis of baseline liver biochemical parameters in 324 cases with novel coronavirus pneumonia in Shanghai area
Abstract: Objective: To summarize the clinical characteristics and liver biochemical parameters of 324 cases admitted with novel coronavirus pneumonia in Shanghai area. Methods: Clinical data and baseline liver biochemical parameters of 324 cases with novel coronavirus pneumonia admitted to the Shanghai Public Health Clinical Center from January 20, 2020 to February 24, 2020 were retrospectively analyzed. Patients were divided into two groups based on the status of illness: mild type (mild and typical) and severe type (severe and critical).The differences in clinical data and baseline liver biochemical parameters of the two groups were described and compared. The t-test and Wilcoxon rank-sum test were used for measurement data. The enumeration data were expressed by frequency and rate, and chi-square test was used. Results: Of the 324 cases with novel coronavirus pneumonia, 26 were severe cases (8%), with median onset of 5 days, 20 cases were HBsAg positive (6.2%), and 70 cases (21.6%) with fatty liver, diagnosed with X-ray computed tomography. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), -glutamyl transferase (GGT), total bilirubin (TBil), albumin(ALB) and international normalized ratio (INR) of 324 cases at baseline were 27.86 20.02 U/L, 29.33 21.02 U/L, 59.93 18.96 U / L, 39.00 54.44 U/L, 9.46 4.58 mol / L, 40.64 4.13 g / L and 1.02 0.10. Of which, ALT was > than the upper limit of normal (> ULN), accounting for 15.7% (51/324). ALT and AST > ULN, accounting for 10.5% (34/324). ALP > ULN, accounting for 1.2% (4/324). ALP and GGT > ULN, accounting for 0.9% (3/324). INR > ULN was lowest, accounting for 0.6% (2/324). There were no statistically significant differences (P > 0.05) in ALT [(21.5 vs. 26) U / L, P = 0.093], ALP [(57 vs.59) U/L, P = 0.674], and GGT [(24 vs.28) U/L, P = 0.101] between the severe group and the mild group. There were statistically significant differences in AST (23 U/L vs. 34 U/L, P < 0.01), TBil (10.75 vs. 8.05 mol / L, P < 0.01), ALB (35.79 4.75 vs. 41.07 3.80 g/L, P < 0.01), and INR (1.00 vs. 1.04, P < 0.01). Conclusion: The baseline liver biochemical parameters of 324 cases with novel coronavirus pneumonia in Shanghai area was comparatively lower and the liverinjury degree was mild, and the bile duct cell damage was rare.
Published: 2020
Journal: Zhonghua Gan Zang Bing Za Zhi
Author Name: Qian, Z P
Author link: https://covid19-data.nist.gov/pid/rest/local/author/qian_z_p
Author Name: Mei, X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/mei_x
Author Name: Zhang, Y Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_y_y
Author Name: Zou, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zou_y
Author Name: Zhang, Z G
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_z_g
Author Name: Zhu, H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhu_h
Author Name: Guo, H Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/guo_h_y
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Ling, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ling_y
Author Name: Zhang, X Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_x_y
Author Name: Wang, J F
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_j_f
Author Name: Lu, H Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/lu_h_z
license: unk
license_url: [unknown license]
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #46734
has_full_text: FALSE
G_ID: analysis_of_baseline_liver_biochemical_parameters_in_324_cases_with_novel_coronavirus
S2 ID: 215612367