altered regional cortical thickness and subcortical volume in women with primary dysmenorrhoea CORD-Papers-2021-10-25 (Version 1)

Title: Altered regional cortical thickness and subcortical volume in women with primary dysmenorrhoea.
Abstract: BACKGROUND There is emerging evidence that primary dysmenorrhoea (PDM) is associated with altered brain function and structure. However, few studies have investigated changes in regional cortical thickness and subcortical volumes in PDM patients. The purpose of this study was to characterize differences in both cortical thickness and subcortical volumes between PDM patients and healthy controls (HCs). METHODS T1-weighted magnetic resonance images were obtained from 44 PDM patients and 32 HCs matched for age and handedness. Cortical thickness was compared in multiple locations across the continuous cortical surface, and subcortical volumes were compared on a structure-by-structure basis. Correlation analysis was then used to evaluate relationships between the clinical symptoms and abnormal brain structure in PDM. RESULTS PDM patients had significantly increased cortical thickness in the orbitofrontal cortex (OFC), insula (IN), primary/secondary sensory area (SI/SII), superior temporal cortex (STC), precuneus (pCUN) and posterior cingulate cortex (PCC). Meanwhile, significantly decreased subcortical volumes of the caudate, thalamus and amygdala were found in PDM patients. Moreover, there were significant positive correlations between the PDM-related duration and the OFC, SFC, STC and IN. The MPQ scores were positively correlated with the pCUN. CONCLUSIONS These findings provide further evidence for grey matter changes in patients with PDM, and in addition, the results support relationships between the structural abnormalities and their role in symptom production. All these results are likely to be potential valuable to provide us with direct information about the neural basis of PDM.
Published: 2016
Journal: European journal of pain
DOI: 10.1002/ejp.753
DOI_URL: http://doi.org/10.1002/ejp.753
Author Name: Liu, P
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_p
Author Name: Yang, J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yang_j
Author Name: Wang, G
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_g
Author Name: Liu, Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_y
Author Name: Liu, X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_x
Author Name: Jin, L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jin_l
Author Name: Liang, F
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liang_f
Author Name: Qin, W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/qin_w
Author Name: Calhoun, V D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/calhoun_v_d
license: unk
license_url: [unknown license]
source_x: Medline
source_x_url: https://www.medline.com/
pubmed_id: 26223337
pubmed_id_url: https://www.ncbi.nlm.nih.gov/pubmed/26223337
url: https://doi.org/10.1002/ejp.753 https://www.ncbi.nlm.nih.gov/pubmed/26223337/
has_full_text: FALSE
G_ID: altered_regional_cortical_thickness_and_subcortical_volume_in_women_with_primary_dysmenorrhoea
S2 ID: 19211241