a clinical multi center study of pregnant women with covid 19 in hubei china CORD-Papers (Version 1)

Title: A Clinical Multi-center Study of Pregnant Women with COVID-19 in Hubei China
Abstract: Background: Coronavirus disease 2019 (COVID-19) has rapidly spread to more than 200 countries. Thus far reports regarding multi-center data from throughout gestation in women with COVID-19 and newborn outcomes are scarce. Methods: : We retrospectively reviewed data from 92 pregnant women with COVID-19 (PW-COVID-19) and their 78 newborns from 27 hospitals in 12 regions of Hubei China. The demographic epidemiological clinical laboratory and therapeutic data and pregnancy perinatal and neonatal outcomes were analyzed. Follow-up was censored until April 7 2020. Findings: Median maternal age was 31.0 years (IQR 280-330) with nine patients in the first trimester five in the second trimester and 78 in the third trimester. None of the patients died and most (924%) recovered and were discharged. Seventy-five deliveries (including three sets of twins) comprised 66 cesarean sections and nine vaginal deliveries with 21 preterm and 57 full-term infants. Seventeen live births had radiological findings of pulmonary infection. One newborn tested positive for SARS-CoV-2 nucleic acid and three newborns were viral antibody-positive: two IgG (+) and IgM (-) and one IgG (+) and IgM (+). The median suspected duration of virus exposure was 7 days (IQR 0 to 27). Interpretation: Compared to the pregnant women with other viral infections such as SARS MERS and Zika virus infection PW-COVID-19 had similar manifestations and relatively better outcomes. The termination time and delivery mode in PW-COVID-19 should be evaluated based on both the maternal and fetal situations. The possibility of maternal-to-fetal transmission of SARS-CoV-2 requires further investigation.Authors Shujie Liao and Renjie Wang contributed equally to this work.
Published: 2020
DOI: 10.21203/rs.3.rs-27398/v1
DOI_URL: http://doi.org/10.21203/rs.3.rs-27398/v1
Author Name: Liao Shujie Wang R
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liao_shujie_wang_r
Author Name: Wu D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wu_d
Author Name: Fang D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/fang_d
Author Name: Dong D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/dong_d
Author Name: Tao Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/tao_z
Author Name: Yang H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/yang_h
Author Name: Zeng W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zeng_w
Author Name: Peng Q
Author link: https://covid19-data.nist.gov/pid/rest/local/author/peng_q
Author Name: Peng J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/peng_j
Author Name: Wu Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wu_y
Author Name: Chen S
Author link: https://covid19-data.nist.gov/pid/rest/local/author/chen_s
Author Name: Lin X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/lin_x
Author Name: Xiong G
Author link: https://covid19-data.nist.gov/pid/rest/local/author/xiong_g
Author Name: Ma X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/ma_x
Author Name: You A
Author link: https://covid19-data.nist.gov/pid/rest/local/author/you_a
Author Name: Lu L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/lu_l
Author Name: Dai W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/dai_w
Author Name: Hu C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/hu_c
Author Name: Zheng J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zheng_j
Author Name: Xiao F
Author link: https://covid19-data.nist.gov/pid/rest/local/author/xiao_f
Author Name: Wang Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_y
Author Name: He W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/he_w
Author Name: Li H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/li_h
Author Name: Xing H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/xing_h
Author Name: Huang Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/huang_y
Author Name: Sun D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/sun_d
Author Name: Cheng P
Author link: https://covid19-data.nist.gov/pid/rest/local/author/cheng_p
Author Name: Jin H
Author link: https://covid19-data.nist.gov/pid/rest/local/author/jin_h
Author Name: Zhang Z
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_z
Author Name: Su D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/su_d
Author Name: Huang R
Author link: https://covid19-data.nist.gov/pid/rest/local/author/huang_r
Author Name: Zhang C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_c
Author Name: Liu X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/liu_x
Author Name: Bi Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/bi_y
Author Name: Wang L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_l
Author Name: Hu X
Author link: https://covid19-data.nist.gov/pid/rest/local/author/hu_x
Author Name: Shen Q
Author link: https://covid19-data.nist.gov/pid/rest/local/author/shen_q
Author Name: Zhao L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhao_l
Author Name: Fu C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/fu_c
Author Name: Dai S
Author link: https://covid19-data.nist.gov/pid/rest/local/author/dai_s
Author Name: Du R
Author link: https://covid19-data.nist.gov/pid/rest/local/author/du_r
Author Name: Wu J
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wu_j
Author Name: Wang S
Author link: https://covid19-data.nist.gov/pid/rest/local/author/wang_s
Author Name: Lv D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/lv_d
Author Name: Long R
Author link: https://covid19-data.nist.gov/pid/rest/local/author/long_r
Author Name: Qian C
Author link: https://covid19-data.nist.gov/pid/rest/local/author/qian_c
Author Name: Pan Wei Zhao Y
Author link: https://covid19-data.nist.gov/pid/rest/local/author/pan_wei_zhao_y
Author Name: Feng L
Author link: https://covid19-data.nist.gov/pid/rest/local/author/feng_l
Author Name: Deng D
Author link: https://covid19-data.nist.gov/pid/rest/local/author/deng_d
Author Name: Zhang W
Author link: https://covid19-data.nist.gov/pid/rest/local/author/zhang_w
license: cc-by
license_url: https://creativecommons.org/licenses/by/4.0/
source_x: WHO
source_x_url: https://www.who.int/
who_covidence_id: #ppcovidwho-315413
url: https://doi.org/10.21203/rs.3.rs-27398/v1
has_full_text: FALSE
G_ID: a_clinical_multi_center_study_of_pregnant_women_with_covid_19_in_hubei_china